ANVS

Annovis Bio Inc

NYSE

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ANVS

Annovis Bio Inc

NYSE

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Here Today PremiumMember

05/02/24 10:01 AM

Post #353

Wondering when we see all the Class Action notifications against
Dr. Maria L. Maccecchini and her incessant misinformation campaign from last year???

crowin

05/01/24 12:50 PM

Post #352

Re: #350: @tredenwater2 - Looks like they are comin for your $5.51

They almost got my 5.51s
Had sell in at 5.45

I keep raising the sell as it goes up

FooBarAndGrill PremiumMember

05/01/24 9:42 AM

Post #351

Shorts closing out today.

tredenwater2 Free

04/30/24 2:28 PM

Post #350

Re: #343: @crowin - 5.51

Looks like they are comin for your $5.51 shares.

OAN 2 million share registration at $5 isnt even goong to keep the doors open let alone pay for another ph 3. My guess is when the larger whales get what they want the price will go up. Maybe these 2 million are an “appetizer”.

tredenwater2 Free

04/30/24 11:06 AM

Post #349

Re: #347: @tredenwater2 - Ouch. I barely missed it his one. I

Wednesday through Monday is the way of the biotech raiders. Great timing…, I say no, its a crafty game of shock and awe for the thieves. A transfer of wealth if you will by a band of greedy misfits. Any stumble, I mean ANY in the way they release their results and the company’s shareholders get max pain. Looks like they want those 2 million shares the CEO recently filed for dirt cheap. It happens to the best and the worst of them.

McMagyar

04/29/24 9:31 PM

Post #348

But t give healthy babies dangerous modified rna jabs..
Are you done with fda?
Join a general health phenomenal
phototherapy..
It’s a miracle..IMO..
Maybe you just stay healthy theough copper peptide activation..

Not a drug
Not a medicine

I think it’s a miracle..

Join us.. on a different path..
Thisisitinfo.com
Facebook.com/kingdomsevolution

The thugs run the financial markets

This annovis drug should already be available for the death sentenced demntia sufferers.. sorry it’s not.. we are betrayed by a corrupted system

tredenwater2 Free

04/29/24 6:39 PM

Post #347

Re: #346: @crowin - Good day here for me, in 5.51

Ouch. I barely missed it his one. I was thinking of dipping a toe recently in the $8-$10 range and glad I didnt chase it on their financing announcement. In hindsight it seems a bit smarmy on the surface announcing a financing round a day or two before releasing data when management knew how the market was going to react. Its an evil necessity but financing young biotechs is as brutal as it gets.

With a second phase 3 needed this company is in for a really long haul.

crowin

04/29/24 1:41 PM

Post #346

Good day here for me, in 5.51 and climbing..8.26 right now

DewDiligence PremiumMember

04/29/24 12:38 PM

Post #345

Re: #335: @Here Today - No. The news was stellar but the MM’s

The trial missed on_both primary endpoints: ADAS-CGIC and ADAS-ADL.

extrooper

04/29/24 12:06 PM

Post #344

Great news in a needed therapy while shorts work to destroy the company.

crowin

04/29/24 11:52 AM

Post #343

Re: #342: @crowin - where is bottom?

5.51

crowin

04/29/24 11:36 AM

Post #342

where is bottom?

FooBarAndGrill PremiumMember

04/29/24 11:27 AM

Post #341

Re: #338: @Here Today - Looks like the MM’s are trying to shake

5-minute halts followed by 30-second trading windows.
Makes for an interesting L2 queue.

stock1ace1 Free

04/29/24 11:26 AM

Post #340

Re: #338: @Here Today - Looks like the MM’s are trying to shake

thats called shareholders selling into bad news with a low float reason for volatility halts

stock1ace1 Free

04/29/24 11:25 AM

Post #339

Re: #335: @Here Today - No. The news was stellar but the MM’s

They missed endpoint ? Thats not good ->

Annovis Bio Shares Sink After Buntanetap Study Misses Endpoint
Mentioned: ANVS
By Dean Seal

Shares of Annovis Bio plummeted after the phase 2/3 study of its drug candidate buntanetap as a treatment for Alzheimer's disease missed a primary endpoint.

The stock was down 59% at $7.32 on heavy volume, with several pauses for volatility. Shares were trading around $14.57 a year ago and have swung between a high of $22.49 and a low of $5.42 in the past 12 months.

The clinical-stage drug-platform company said Monday that the phase 2/3 trial showed buntanetap producing a significantly higher rate of improvement in cognition assessment scores at each treatment dose relative to a placebo.

But another endpoint in the study, examining the drug's impact based on an assessment called Clinician's Global Impression of Change, was not met, with no statistically significant difference observed across all dosing groups of patients compared with a placebo group.

Annovis said the assessment is more subjective, allowing for a greater placebo effect as patients and caregivers were likely hopeful for a change.

The company said it plans to conduct a phase 3 study to confirm and expand its findings in an 18-month disease-modifying trial.

Write to Dean Seal at dean.seal@wsj.com

(END) Dow Jones Newswires

April 29, 2024 11:18 ET (15:18 GMT)
Copyright (c) 2024 Dow Jones & Company, Inc.

Here Today PremiumMember

04/29/24 11:24 AM

Post #338

Looks like the MM’s are trying to shake out all those Stop Losses and reset the 52 week low at the same time. Criminal…

FooBarAndGrill PremiumMember

04/29/24 11:10 AM

Post #337

Out of 325 patients who completed the Phase II/III trial, 202 had a ratio of pTau217/tTau≥4.2% that indicates AD.

Here Today PremiumMember

04/29/24 11:08 AM

Post #336

In my honest opinion, MM’s and those who are short (over 17% of float is shorted legally- who knows how many illegal/naked shares are shorted) were not expecting this news today.

Here Today PremiumMember

04/29/24 11:03 AM

Post #335

Re: #334: @stock1ace1 - The ground you mean ? Bad news

No. The news was stellar but the MM’s are doing what they do best.

stock1ace1 Free

04/29/24 10:56 AM

Post #334

Re: #330: @Here Today - To the MOON!!!!!!!

The ground you mean ? Bad news

stock1ace1 Free

04/29/24 10:55 AM

Post #333

Re: #331: @Here Today - Wonder what it opens back up at after

FooBarAndGrill PremiumMember

04/29/24 10:30 AM

Post #332

Hey Annovis, ... Next time, Compose the 8K BEFORE the halt.

Here Today PremiumMember

04/29/24 10:13 AM

Post #331

Wonder what it opens back up at after the Halt.

Here Today PremiumMember

04/29/24 10:13 AM

Post #330

Re: #329: @FooBarAndGrill - Halted T1 news pending.

To the MOON!!!!!!!

FooBarAndGrill PremiumMember

04/29/24 10:04 AM

Post #329

Halted T1 news pending.
https://www.nasdaqtrader.com/trader.aspx?id=TradeHalts#

runncoach

04/27/24 8:14 AM

Post #328

Re: #326: @FooBarAndGrill - The 8K announces an ELOC. "Equity Line

Probably the best financing agreement I have seen on one of these alternative AD plays. Seemingly shows a lot of confidence in the upcoming results.

dinogreeves PremiumMember

04/26/24 8:26 PM

Post #327

Fantastic move today.

FooBarAndGrill PremiumMember

04/26/24 4:03 PM

Post #326

The 8K announces an ELOC. "Equity Line of Credit"

FooBarAndGrill PremiumMember

04/26/24 12:50 PM

Post #325

8K
https://www.sec.gov/ix?doc=/Archives/edgar/data/0001477845/000110465924052471/tm2412796d1_8k.htm

FooBarAndGrill PremiumMember

04/26/24 12:47 PM

Post #324

REGISTRATION RIGHTS AGREEMENT
https://www.sec.gov/ix?doc=/Archives/edgar/data/0001477845/000110465924052471/tm2412796d1_8k.htm

FooBarAndGrill PremiumMember

04/26/24 12:46 PM

Post #323

COMMON STOCK PURCHASE AGREEMENT
https://www.sec.gov/ix?doc=/Archives/edgar/data/0001477845/000110465924052471/tm2412796d1_8k.htm

Here Today PremiumMember

04/24/24 8:45 AM

Post #322

I’m guessing this from the last PR failed or at least they should be announcing in the next 5 business days……

“The AD Phase II/III study was completed in February, and we announced that we cleaned the data to our satisfaction and will release top-line efficacy results in April”.

cfoofme

04/17/24 10:25 AM

Post #321

Any ideas why ANVS sp is down so much the last few days. I’ve seen no news, good or bad?

Monksdream PremiumMember

04/02/24 9:15 AM

Post #320

Early Barchart 100
https://www.barchart.com/stocks/performance/percent-change/advances?orderBy=percentChange&orderDir=desc

dinogreeves PremiumMember

04/01/24 9:47 AM

Post #319

Peer reviewed article came out.

dinogreeves PremiumMember

03/30/24 7:56 PM

Post #318

Maybe less than 2 weeks to go for the data to come, at the most 3 weeks, but it could also be next week.

dinogreeves PremiumMember

03/30/24 7:55 PM

Post #317

"This month, the FDA issued guidance on developing drug treatments for early Alzheimer's disease, a must-read for all $ANVS investors. The FDA emphasizes significant clinical improvement as the key outcome. If trials show clinical improvement backed by biomarker data, companies may seek traditional approval. If only biomarkers show improvement and clinical benefits need more time to manifest, accelerated approval might be pursued, contingent on further trials. This aligns with $ANVS's strategy of prioritizing clinical improvement as the primary endpoint in its PD and AD trials. I'm optimistic about the potential for approval based on upcoming PD and/or AD trial outcomes. While longer trials are anticipated, impressive results could pave the way for submitting approval applications almost immediately post-trial. The company has stated that they will meet with the FDA shortly after the trials are read out. It will be very interesting to see if they're given the ok to apply..."

dinogreeves PremiumMember

03/28/24 10:36 PM

Post #316

Looks like maybe some small news tomorrow, damn on Good Friday, really? C'mon now.

dinogreeves PremiumMember

03/27/24 12:24 PM

Post #315

Next week it's April, two datas should be released AD and PD, if they blow it out of the park with news, straight to a billion market cap, hero or zero. They also have 250 million shelf offering, if the data is great one institution could gobble those up.

dinogreeves PremiumMember

03/25/24 10:38 PM

Post #314

Re: #313: @dinogreeves - Monk, very volatile especially with this one low

Odds are 30% data it will be a success, 70% chance a failure. If they blow out of the park with the data on AD and PD, this will run easy to billion market cap.

dinogreeves PremiumMember

03/25/24 2:07 PM

Post #313

Re: #312: @Monksdream - Parkinson and Alzheimer drug discovery companies are volatile

Monk, very volatile especially with this one low floater, this one is either a hero or a zero after the data.

Monksdream PremiumMember

03/22/24 10:14 AM

Post #312

Parkinson and Alzheimer drug discovery companies are volatile
It’s come up off the mat

dinogreeves PremiumMember

03/21/24 8:44 PM

Post #311

"Subject to Certain Exceptions". Something is about to happen with this one next month. Good luck everyone.

Here Today PremiumMember

03/20/24 12:40 PM

Post #310

I also believe with only 11 million shares outstanding, of which 26% is held by insiders and 12 % held by institutions, this could see an epic run with great results.
Just my opinion. Good luck

Here Today PremiumMember

03/20/24 12:36 PM

Post #309

Re: #307: @x man - maybe a short squeeze....20% of float is short.

If CT results are stellar, I’m thinking we could see a run like what happened with Viking Therapeutics recently in my opinion.

Here Today PremiumMember

03/20/24 12:34 PM

Post #308

Re: #307: @x man - maybe a short squeeze....20% of float is short.

I just saw the announcement that they will be providing TopLine data in April. So progress has been made and let’s see what happens now! Good luck and hopefully this truly can help those in need of this drug for their ailment.