News for 'CYTR' - (CytRx Corporation Subsidiary, RXi Pharmaceuticals, Licenses ``Nanotransporters' and Other RNAi Discoveries from the University of Massachusetts Medical School - Novel Technology May Enable Systemic RNAi Delivery -)
WORCESTER, Mass., Jan 11, 2007 (BUSINESS WIRE) -- CytRx Corporation
(NASDAQ:CYTR) today announced that RXi Pharmaceuticals Corporation (RXi), a
majority-owned subsidiary of CytRx, has entered into significant new agreements
with the University of Massachusetts Medical School (UMMS) to license RNA
interference (RNAi) intellectual property for all therapeutic applications. RNAi
has been shown to effectively interfere with the expression of targeted
disease-associated genes with great specificity and potency, and was
co-discovered by 2006 Nobel Laureate Dr. Craig C. Mello, who is expected to
become a scientific advisor of RXi pending institutional approval. The
agreements include an exclusive therapeutic license with rights to sublicense
for nanotransporters, which have been shown to deliver intact RNAi to a number
of tissues in animal models. The licenses are contingent upon RXi's receipt of
working capital funding in the coming months. Financial terms were not disclosed
for competitive reasons.
Tod Woolf, Ph.D., CEO of RXi, stated, "The scientists that founded RXi realized
long ago that delivery technology was the key to systemic administration of
RNAi. The nanotransporters are the culmination of work carried out since 2003 by
Dr. Tariq Rana of UMMS. This new technology, together with our existing
RNAi-based intellectual property licenses acquired from CytRx, extraordinary
scientific advisors and proven management team provides the foundation required
to establish RXi as a pre-eminent company focused exclusively on the RNAi field.
With Merck's acquisition of Sirna Therapeutics, RXi expects to compete primarily
with industry leader Alnylam Pharmaceuticals as a company dedicated to
developing and commercializing RNAi therapeutics. While other competitors have
sought collaborators to obtain systemic delivery of RNAi, RXi now has its own
potential enabling delivery technology," added Dr. Woolf.
"If RXi is able to offer a new method for treating a broad range of diseases,
RNAi therapeutics could become as important as small molecules and antibody
drugs," said Steven A. Kriegsman, President and CEO of CytRx.
Licensed Nanotransporter Technology
Tariq M. Rana, Ph.D., Professor and Founding Director of the Program in Chemical
Biology at UMMS and developer of the nanotransporters, has reported activity
with RNAi delivered with nanotransporters in mouse models at 1 milligram per
kilogram - an exceptionally favorable dose. The nanotransporters are highly
uniform in structure and are readily formulated by simply mixing with RNAi
compounds. Results of this research were presented at the 2006 Keystone
Conference.
The RXi licensed technology also includes compounds for the potential treatment
of amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) that can be
delivered locally to the central nervous system. The ability to control gene
expression in the central nervous system has potentially far-reaching
implications for the treatment of a number of neurodegenerative diseases. In
addition, the technology includes methods of targeting point mutations with RNAi
that may be useful in targeting mutations that cause certain cancers and genetic
diseases.
About CytRx Corporation
CytRx Corporation is a biopharmaceutical research and development company
engaged in the development of high-value human therapeutics. The Company owns
three clinical-stage compounds based on its small molecule "molecular chaperone"
co-induction technology. In September 2006 CytRx announced that arimoclomol was
shown to be safe and well tolerated at all three doses tested in its Phase IIa
clinical trial in patients with ALS. The Company plans to enter a Phase IIb
clinical trial with arimoclomol in ALS in the third quarter of 2007, subject to
U.S. Food and Drug Administration (FDA) approval. The FDA has granted Fast Track
designation and Orphan Drug status to arimoclomol for the treatment of ALS. Also
in September 2006, CytRx announced receipt of $24.5 million in a non-dilutive
agreement with the privately funded ALS Charitable Remainder Trust to fund
continued arimoclomol development for the treatment for ALS in return for a 1%
royalty from potential worldwide sales of arimoclomol for the treatment of ALS.
The Greater Los Angeles Chapter of The ALS Association is the charitable
beneficiary of the ALS Charitable Remainder Trust. For more information on the
Company, visit CytRx's Web site at www.cytrx.com.
About RXi Pharmaceuticals Corporation
Massachusetts-based RXi is a biopharmaceutical research and development company
that will focus on developing RNAi-based therapeutics for the treatment of human
disease. RXi's initial focus will be on neurodegenerative diseases, oncology,
type 2 diabetes and obesity. RXi has licenses to a diverse series of early
patents and patent applications that were filed from 1998-2006 in the areas of
RNAi target sequences, RNAi chemistry and RNAi delivery. The company is co-owned
by CytRx and RNAi pioneers Craig C. Mello, Ph.D., 2006 Nobel Laureate for
co-discovering RNAi, Tariq M. Rana, Ph.D., inventor of fundamental technology
for stabilizing RNAi and of RNAi nanotransporters, Gregory J. Hannon, Ph.D.,
discoverer of RNAi mechanism (RISC) and short hairpin RNAi (shRNAi), and Michael
P. Czech, Ph.D., a leader in the application of RNAi to diabetes and obesity.
RXi's CEO, Tod Woolf, Ph.D., previously co-invented and commercialized
STEALTH(TM) RNAi, one of the most widely used second-generation RNAi research
products.
About the University of Massachusetts Medical School
The University of Massachusetts Medical School, one of the fastest growing
academic health centers in the country, has built a reputation as a world-class
research institution, consistently producing noteworthy advances in clinical and
basic research. UMMS attracts more than $174 million in research funding
annually, 80% of which comes from federal funding sources. Research funding
enables UMMS scientists to explore human disease from the molecular level to
large-scale clinical trials. Basic and clinical research leads to new approaches
for diagnosis, treatment and prevention of disease. Visit www.umassmed.edu for
additional information.
Forward-Looking Statements
This press release may contain forward-looking statements (statements as to
matters other than historical facts) as defined in the Private Securities
Litigation Reform Act of 1995 and in Section 27A of the Securities Act of 1933,
as amended, and Section 21E of the Securities Exchange Act of 1934, as amended.
Such statements involve risks and uncertainties that could cause actual events
or results to differ materially from the events or results described in the
forward looking statements. Examples of such risks and uncertainties include,
but are not limited to, the need for RXi to obtain significant financing in the
coming months for which it does not yet have commitments, the need for RXi to
meet specified milestones to maintain the UMMS licenses, RXi's need to raise
significant capital to fund operations and development of its potential
products, the need to establish management and other infrastructure for the RXi
subsidiary, intense competition with other companies focused on RNAi and other
larger companies with RNAi programs and with other existing or new therapeutic
modalities, the early stage of development of RXi's technology, and the scope,
timing and outcome of pre-clinical and clinical testing and regulatory review of
RXi's potential products. Additional risks or uncertainties are described in
CytRx's most recently filed SEC documents, such as its most recent annual report
on Form 10-K, all quarterly reports on Form 10-Q and any current reports on Form
8-K filed since the date of the last Form 10-K. All forward-looking statements
are based upon information available to CytRx on the date the statements are
first published. CytRx undertakes no obligation to publicly update or revise any
forward-looking statements, whether as a result of new information, future
events or otherwise.
SOURCE: CytRx Corporation
CONTACT: CytRx CorporationCEOcast, Inc.Dan Schustack, 212-732-4300dschustack@ceocast.com
Copyright Business Wire 2007
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